Characterization of a novel SXT/R391 Integrative and Conjugative Element carrying cfr, blaCTX-M-65, fosA3 and aac(6')-Ib-cr in Proteus mirabilis [PublishAheadOfPrint]

A novel 139,487-bp SXT/R391 Integrative and Conjugative Element, ICEPmiChnBCP11, was characterized in Proteus mirabilis of swine origin in China. ICEPmiChnBCP11 harbors twenty different antimicrobial resistance genes, including clinically important rRNA methyltransferase gene cfr, extended-spectrum β-lactamase gene bla_CTX-M-65, fosfomycin resistance gene fosA3 and fluoroquinolones resistance gene aac(6')-Ib-cr. An ISPpu12-mediated composite transposon containing various resistance genes and ten copies of IS26 is inserted in hot spot 4. ICEPmiChnBCP11 was successfully transferred to Escherichia coli.

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