Predictors of Peripherally Inserted Central Catheter Occlusion in the Outpatient Parenteral Antimicrobial Therapy Setting [PublishAheadOfPrint]

In this retrospective study of 285 patients receiving outpatient parenteral antibiotic therapy (OPAT), duration of antibiotic, use of double-lumen catheters, and receipt of penicillin G and cloxacillin appeared to increase the risk of PICC occlusion. Physicians should consider these factors when prescribing long-term antibiotic therapy. Further studies are needed to evaluate methods to reduce PICC occlusion, particularly when double-lumen PICCs are necessary, and when cloxacillin or penicillin G are the preferred treatment.

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