Successful desensitization in a pediatric patient with acetazolamide allergy

Acetazolamide is an uncommon cause of IgE-mediated drug allergy. Classified as a sulfonamide, acetazolamide differs in chemical structure from sulfonamide antibiotics as it does not have an amine moiety at the N4 position. As a result, acetazolamide is infrequently a cause of IgE-mediated drug reactions and is less-likely to be cross-reactive in those with IgE-mediated allergy to sulfonamide antibiotics.1,2 Acetazolamide is reported to trigger non-IgE mediated reactions including pulmonary edema, delirium, acute generalized exanthematous pustulosis, and even Steven Johnsons syndrome.

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