Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death [Neuroscience]

Dravet syndrome is a catastrophic, pharmacoresistant epileptic encephalopathy. Disease onset occurs in the first year of life, followed by developmental delay with cognitive and behavioral dysfunction and substantially elevated risk of premature death. The majority of affected individuals harbor a loss-of-function mutation in one allele of SCN1A, which encodes the...

https://ift.tt/2Bynzw5