Serum Factor V is a Continuous Biomarker of Graft Dysfunction and a Predictor of Graft Loss After Liver Transplantation

Background: Factor V has never been compared to a validated early allograft dysfunction (EAD) definition. We aimed to assess Factor V as a biomarker of EAD and a predictor of graft loss after liver transplantation (LT). Methods: We retrospectively assessed the serum Factor V levels on postoperative day 1 after LT. Patients were divided according to their Factor V levels into the ≤36.1U/mL and >36.1U/mL groups. The primary outcome was graft loss within 1, 3, and 6 months. The secondary outcome was EAD, as defined by Olthoff et al Predictors of outcomes were identified by multivariable logistic regression. Results: 227 patients were included in the study: 74 with Factor V ≤36.1U/mL and 153 with Factor V >36.1U/mL. EAD was diagnosed in 41/74 (55.4%) patients with Factor V ≤36.1U/mL and in 20/153 (13.1%) patients with Factor V >36.1U/mL (p36.1U/mL (p=0.001). Factor V was a continuous predictor for 3- and 6-month graft loss [(OR=0.96 (95%CI 0.94–0.99) and OR=0.97 (95% CI 0.94–0.99) per U/mL], whereas EAD was not significant when adjusted for Factor V. Conclusion: Factor V is an early marker for EAD and is a continuous predictor of short-term graft loss after LT. Corresponding Author: Dr. Cleber Rosito Pinto Kruel, Assistant Professor, Liver Transplant Program, Hospital de Clinical de Porto Alegre, 2350 Ramiro Barcelos Street, office 745, Porto Alegre, Brazil, Phone: +55 51 3359 8232. E-mail: crkruel@hcpa.edu.br Authorship: AG has contributed to the study's concept, design, data collection, data analysis, interpretation, and manuscript writing. CP and JEP have contributed to the data collection and approved the manuscript's final version. MFC, ANB, AA, TJMG, IL, ADC, and MRAS have all contributed to the data interpretation and critical appraisal, and they also approved the manuscript's final version. GS and CRPK have contributed to the study's concept, design, data interpretation, and manuscript writing. All authors have approved the manuscript's final version. Category of manuscript: Original investigation Financial Support: None Conflict of Interest: None Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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