Medicine by Sfakianakis Alexandros

A case of DAPSONE INDUCED METHEMOGLOBINEMIA

now

via Latest Results for Journal of Pharmaceutical Policy and Practice

Abstract

Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ toxins, its level starts rising. Once it is > 3%, tissue hypoxia ensues. Here is a case of dapsone induced MetHb and is reported in a young girl with central cyanosis, and was treated successfully with methylene blue. Methemoglobinemia should be considered in differential diagnoses of cyanosed patient with normal ABGs, PaO₂ and cardio-respiratory status. If left untreated, the disease can be fatal.