Pharmaceuticals, Vol. 12, Pages 99: Psychotropic Drugs for the Management of Chronic Pain and Itch Pharmaceuticals doi: 10.3390/ph12020099 Authors: Daria A. Belinskaia Mariia A. Belinskaia Oleg I. Barygin Nina P. Vanchakova Natalia N. Shestakova Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics...
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Pharmaceuticals, Vol. 12, Pages 98: Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells Pharmaceuticals doi: 10.3390/ph12020098 Authors: Ana M. de Matos Alice Martins Teresa Man David Evans Magnus Walter Maria Conceição Oliveira Óscar López José G. Fernandez-Bolaños Philipp Dätwyler Beat Ernst M. Paula Macedo Marialessandra Contino Nicola...
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Pharmaceuticals, Vol. 12, Pages 97: Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses Pharmaceuticals doi: 10.3390/ph12020097 Authors: Miguel A. Martín-Acebes Nereida Jiménez de Oya Juan-Carlos Saiz The Zika virus (ZIKV) is a mosquito-borne flavivirus that can lead to birth defects (microcephaly), ocular lesions and neurological disorders (Guillain-Barré syndrome). There is no licensed vaccine or antiviral treatment...
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Pharmaceuticals, Vol. 12, Pages 96: Ferritin in Kidney and Vascular Related Diseases: Novel Roles for an Old Player Pharmaceuticals doi: 10.3390/ph12020096 Authors: József Balla György Balla Abolfazl Zarjou Iron is at the forefront of a number of pivotal biological processes due to its ability to readily accept and donate electrons. However, this property may also catalyze the generation of free radicals with ensuing cellular and tissue toxicity. Accordingly, throughout evolution...
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Pharmaceuticals, Vol. 12, Pages 95: Therapeutic Potential of Kappa Opioid Agonists Pharmaceuticals doi: 10.3390/ph12020095 Authors: Tyler C. Beck Matthew A. Hapstack Kyle R. Beck Thomas A. Dix Many original research articles have been published that describe findings and outline areas for the development of kappa-opioid agonists (KOAs) as novel drugs; however, a single review article that summarizes the broad potential for KOAs in drug development does not exist. It is well-established...
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Pharmaceuticals, Vol. 12, Pages 92: CDK8-Novel Therapeutic Opportunities Pharmaceuticals doi: 10.3390/ph12020092 Authors: Ingeborg Menzl Agnieszka Witalisz-Siepracka Veronika Sexl Improvements in cancer therapy frequently stem from the development of new small-molecule inhibitors, paralleled by the identification of biomarkers that can predict the treatment response. Recent evidence supports the idea that cyclin-dependent kinase 8 (CDK8) may represent a potential drug target for...
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Pharmaceuticals, Vol. 12, Pages 93: Cellular Senescence and Iron Dyshomeostasis in Alzheimer’s Disease Pharmaceuticals doi: 10.3390/ph12020093 Authors: Shashank Masaldan Abdel Ali Belaidi Scott Ayton Ashley I. Bush Iron dyshomeostasis is a feature of Alzheimer’s disease (AD). The impact of iron on AD is attributed to its interactions with the central proteins of AD pathology (amyloid precursor protein and tau) and/or through the iron-mediated generation of prooxidant...
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Pharmaceuticals, Vol. 12, Pages 94: Ironing out Macrophage Immunometabolism Pharmaceuticals doi: 10.3390/ph12020094 Authors: Stefania Recalcati Elena Gammella Gaetano Cairo Over the last decade, increasing evidence has reinforced the key role of metabolic reprogramming in macrophage activation. In addition to supporting the specific immune response of different subsets of macrophages, intracellular metabolic pathways also directly control the specialized effector functions of immune...
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Pharmaceuticals, Vol. 12, Pages 91: Synthesis and Study of New Quinolineaminoethanols as Anti-Bacterial Drugs Pharmaceuticals doi: 10.3390/ph12020091 Authors: Pierre Laumaillé Alexandra Dassonville-Klimpt François Peltier Catherine Mullié Claire Andréjak Sophie Da-Nascimento Sandrine Castelain Pascal Sonnet The lack of antibiotics with a novel mode of action associated with the spread of drug resistant bacteria make the fight against infectious diseases particularly...
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Pharmaceuticals, Vol. 12, Pages 89: CK2 Pro-Survival Role in Prostate Cancer Is Mediated via Maintenance and Promotion of Androgen Receptor and NFκB p65 Expression Pharmaceuticals doi: 10.3390/ph12020089 Authors: Janeen H. Trembley Betsy T. Kren Md. J. Abedin Daniel P. Shaughnessy Yingming Li Scott M. Dehm Khalil Ahmed The prosurvival protein kinase CK2, androgen receptor (AR), and nuclear factor kappa B (NFκB) interact in the function of prostate cells, and...
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Pharmaceuticals, Vol. 12, Pages 90: Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells Pharmaceuticals doi: 10.3390/ph12020090 Authors: Charlotte M. Miller Elaine C. O’Sullivan Florence O. McCarthy Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6- and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer...
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Pharmaceuticals, Vol. 12, Pages 88: Correction: Klingler, M., et al. Cholecystokinin-2 Receptor Targeting with Novel C-terminally Stabilized HYNIC-Minigastrin Analogs Radiolabeled with Technetium-99m. Pharmaceuticals 2019, 12, 13 Pharmaceuticals doi: 10.3390/ph12020088 Authors: Maximilian Klingler Christine Rangger Dominik Summer Piriya Kaeopookum Clemens Decristoforo Elisabeth von Guggenberg In our paper [...]
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