Pharmaceuticals, Vol. 12, Pages 87: Cysteine Cathepsin Protease Inhibition: An update on its Diagnostic, Prognostic and Therapeutic Potential in Cancer Pharmaceuticals doi: 10.3390/ph12020087 Authors: Surinder M. Soond Maria V. Kozhevnikova Paul A. Townsend Andrey A. Zamyatnin In keeping with recent developments in basic research; the importance of the Cathepsins as targets in cancer therapy have taken on increasing importance and given rise to a number of key areas of interest...
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Pharmaceuticals, Vol. 12, Pages 86: Recent Developments in Peptidyl Diaryl Phoshonates as Inhibitors and Activity-Based Probes for Serine Proteases Pharmaceuticals doi: 10.3390/ph12020086 Authors: Marta Maślanka Artur Mucha This review presents current achievements in peptidyl diaryl phosphonates as covalent, specific mechanism-based inhibitors of serine proteases. Along three decades diaryl phosphonates have emerged as invaluable tools in fundamental and applicative studies involving...
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Pharmaceuticals, Vol. 12, Pages 83: Voltammetric Evaluation of Diclofenac Tablets Samples through Carbon Black-Based Electrodes Pharmaceuticals doi: 10.3390/ph12020083 Authors: Carlos Eduardo Peixoto da Cunha Edson Silvio Batista Rodrigues Morgana Fernandes Alecrim Douglas Vieira Thomaz Isaac Yves Lopes Macêdo Luane Ferreira Garcia Jerônimo Raimundo de Oliveira Neto Emily Kussmaul Gonçalves Moreno Nara Ballaminut Eric de Souza Gil Diclofenac (DIC) is a non-steroidal...
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Pharmaceuticals, Vol. 12, Pages 85: 1,2-Dihydroxyxanthone: Effect on A375-C5 Melanoma Cell Growth Associated with Interference with THP-1 Human Macrophage Activity Pharmaceuticals doi: 10.3390/ph12020085 Authors: Viviana Silva Fátima Cerqueira Nair Nazareth Rui Medeiros Amélia Sarmento Emília Sousa Madalena Pinto Xanthones have been suggested as prospective candidates for cancer treatment. 1,2- dihydroxyxanthone (1,2-DHX) is known to interfere with the growth of several...
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Pharmaceuticals, Vol. 12, Pages 84: Developments in Carbohydrate-Based Cancer Therapeutics Pharmaceuticals doi: 10.3390/ph12020084 Authors: Farzana Hossain Peter R. Andreana Cancer cells of diverse origins express extracellular tumor-specific carbohydrate antigens (TACAs) because of aberrant glycosylation. Overexpressed TACAs on the surface of tumor cells are considered biomarkers for cancer detection and have always been prioritized for the development of novel carbohydrate-based...
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Pharmaceuticals, Vol. 12, Pages 82: De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria Pharmaceuticals doi: 10.3390/ph12020082 Authors: Boris Vishnepolsky George Zaalishvili Margarita Karapetian Tornike Nasrashvili Nato Kuljanishvili Andrei Gabrielian Alex Rosenthal Darrell E. Hurt Michael Tartakovsky Maya Grigolava Malak Pirtskhalava Antimicrobial peptides (AMPs) have been identified as a potentially new class of...
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Pharmaceuticals, Vol. 12, Pages 81: Cardiolipin-Based Lipopolyplex Platform for the Delivery of Diverse Nucleic Acids into Gram-Negative Bacteria Pharmaceuticals doi: 10.3390/ph12020081 Authors: Federico Perche Tony Le Gall Tristan Montier Chantal Pichon Jean-Marc Malinge Antibiotic resistance is a growing public health concern. Because only a few novel classes of antibiotics have been developed in the last 40 years, such as the class of oxazolidinones, new antibacterial...
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