Plazomicin activity against 346 Extended-Spectrum-{beta}-lactamase/AmpC-producing Escherichia coli urinary isolates, related to aminoglycoside-modifying enzymes characterized. [PublishAheadOfPrint]

The activity of plazomicin and clinically relevant aminoglycosides were tested against 346 ESBL/AmpC-producer Escherichia coli urinary isolates and the results were correlated with the presence of aminoglycoside-modifying enzymes (AMEs).

Data showed that plazomicin was very active against all ESBL/AmpC-producing E. coli urinary isolates. Its activity was not related to the AME genes studied.

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