Reply to Candel et al.: Evidence for evolutionary conservation of folding kinetics in the thioredoxin protein family [Biological Sciences]

The letter by Candel et al. (1) does not address a potential problem with their own experimental set-up. In particular, the use of guanidinium hydrochloride (GdnHCl) is not the best choice of denaturant for studying a folding reaction. There is an ample amount of evidence to suggest that the variations...

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