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Τρίτη 9 Οκτωβρίου 2018

PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice [Cell Biology]

PAX5 is a well-known haploinsufficient tumor suppressor gene in human B-cell precursor acute lymphoblastic leukemia (B-ALL) and is involved in various chromosomal translocations that fuse a part of PAX5 with other partners. However, the role of PAX5 fusion proteins in B-ALL initiation and transformation is ill-known. We previously reported a...

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