Collusion between neutralizing antibodies and other immune factions in the destruction of adenoviral vectors [Microbiology]

Adenoviral vectors hold great promise for gene therapy, the induction of antitumor immunity, and vaccination against viral infections (1, 2). But sometimes, preexisting antibodies elicited by natural infection with particular types of adenovirus prevent the desired expression of the transgene carried by the vector, such as a replication-defective adenovirus 5....

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