Direct visualization of ion-channel gating in a native environment [Biophysics and Computational Biology]

Pentameric ligand-gated ion channels (pLGICs), also known as Cys-loop receptors, are localized primarily in the postsynaptic membranes, and mediate fast chemical transmission in the central and peripheral nervous systems. Binding of neurotransmitter activates these receptors, causing changes in postsynaptic membrane potential and consequently modulation of neuronal or muscle activity. pLGIC...

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