Ryanodine receptor cluster size sets the tone in cerebral smooth muscle [Physiology]

Ryanodine receptors (RyRs) are large intracellular Ca2+ channels that provide the molecular basis of the process termed Ca2+-induced Ca2+ release (1). Ca2+ signaling through RyRs has been shown to be critical for skeletal, cardiac, and smooth muscle physiology (2) as well as for neurons (3) and secretory cells like pancreatic...

https://ift.tt/2OQ5Jty