Effects of articular disc or condylar cartilage resection on mandibular growth in young rats

Publication date: Available online 9 October 2018

Source: Archives of Oral Biology

Author(s): Shuo Chen, Lin-hai He, Lu Zhao, E. Xiao, Yang He, Yi Zhang

Abstract

Objective

This study was aimed to compare the effects of articular disc and condylar cartilage resection on mandibular growth in Sprague Dawley rats.

Design

Eighty-four male Sprague Dawley rats (age = 4 weeks) were grouped according to the following procedures: group A (n = 21), exclusive surgical exposure of articular disc and condylar cartilage; group B (n = 21), exclusive surgical resection of articular disc; group C (n = 21), exclusive surgical resection of condylar cartilage; group D (n = 21), surgical resection of both articular disc and condylar cartilage. All surgery was performed in unilateral. One rat was killed in each group immediately after the surgery. Hematoxylin and eosin (H&E) staining was used to confirm the completely removal of the disc or cartilage. Five rats in the four groups were sacrificed in 1, 3, 6, and 9 weeks post-operation. The heights and lengths of the mandibles were measured and analyzed statistically.

Results

The mandibular height of group D (5.01 ± 0.25 mm) was statistically lower than group A (5.59 ± 0.17 mm) at 1 week post-operation. The height of group C (5.62 ± 0.26 mm) was significantly lower than group A (6.27 ± 0.31 mm) 3 weeks after surgery. The height of group B (6.38 ± 0.36 mm) was significantly lower than group A (6.95 ± 0.10 mm) 6 weeks after surgery. At 9 weeks post-operation, the mandibular heights in groups B, C, and D were lower than group A, group D was lower than group C, and group C was lower than group B. The lengths of the mandibles were not significantly decreased until 9 weeks post-operation in group D.

Conclusions

The increase in mandibular height was interfered after either articular disc or condylar cartilage was resected, and mandibular height deficiency likely occurred earlier and more severely when cartilage was resected. However, the increase in mandibular length was barely interfered when either articular disc or condylar cartilage was resected.

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