Modeling epidermal gene expression in skin cells in vitro

We have reported previously that women whose facial skin appears exceptionally youthful have distinct patterns of epidermal gene expression as compared to women who appear average or older than their actual chronological age. The majority of these epidermal genes (80%) showed a strong negative age-dependency in older-appearing women; by cluster analysis these could be categorized into 20 expression patterns capturing distinct biological pathways. In the current work we used a combined in vitro and in silico approach to determine the extent to which combinations of materials may affect expression of these genes.

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