Background Gastric reflux (GR) is a backflow of gastric content to the aerodigestive tract. GR was previously found to be associated with inflammatory airway diseases and a potential cause of airway remodeling. Chronic exposure to gastric content may induce damage from nose to lung, because digestive enzymes and acidity are toxic to airway epithelial cells. Recently, the toxicity of pepsin in a non‐acidic environment was found to increase proinflammatory cytokines and receptors in the epithelium...
Background Bitter and sweet taste receptors are present in the human upper airway, where they have roles in innate immunity. Previous studies have shown that 1 of the 25 bitter receptors, TAS2R38, responds to specific bacterial signaling molecules and evokes 1 type of a defense response in the upper airway, whereas ligands of sweet receptors suppress other types of defense responses. Methods We examined whether other bitter taste receptors might also be involved in innate immunity by using...
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Publication date: September 2020Source: Annals of Allergy, Asthma & Immunology, Volume 125, Issue 3Author(s): Giorgio Ciprandi, Amelia Licari, Gaetana Filippelli, Maria Angela Tosca, Gian Luigi Marseglia
Publication date: September 2020Source: Annals of Allergy, Asthma & Immunology, Volume 125, Issue 3Author(s):
Publication date: September 2020Source: Annals of Allergy, Asthma & Immunology, Volume 125, Issue 3Author(s):
Publication date: September 2020Source: Annals of Allergy, Asthma & Immunology, Volume 125, Issue 3Author(s):
Publication date: September 2020Source: Annals of Allergy, Asthma & Immunology, Volume 125, Issue 3Author(s):
Publication date: September 2020Source: Annals of Allergy, Asthma & Immunology, Volume 125, Issue 3Author(s): Ayobami T. Akenroye, Robert Wood, Corinne Keet
Publication date: Available online 25 August 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Hyo-In Rhyou, Young-Hee Nam
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