Related Articles Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage. Drug Chem Toxicol. 2020 Aug 24;:1-8 Authors: Cengiz M, Kutlu HM, Peker Cengiz B, Ayhancı A Abstract To investigate the effects of escin (ES) on acute damage induced by alkylating agent, experimental rats were injected with cyclophosphamide (CPM) to cause liver damage. The animals were divided into four groups:...
Wed Aug 26, 2020 13:21
Related Articles Adverse effects of textile dyes on antioxidant enzymes and cholinesterase activities in Drosophila melanogaster (Oregon R+). Drug Chem Toxicol. 2020 Aug 24;:1-9 Authors: Rahimi S, Singh MP, Gupta J Abstract The effluents from textile dyeing industry are causing water pollution and may transform into more toxic and carcinogenic chemical species by environmental conditions. Therefore systemic toxicity of textile dyes is major...
Wed Aug 26, 2020 13:21
Related Articles Ochratoxin a in breast milk in Morocco: the affecting dietary habits of the lactating mothers and the degree of exposure of newborns "CONTAMILK study". Drug Chem Toxicol. 2020 Aug 24;:1-7 Authors: Cherkani-Hassani A, Ghanname I, Zinedine A, Sefrioui H, Qmichou Z, Mouane N Abstract The aim of the present study is to evaluate the level of contamination of breast milk (BM) by ochratoxin A, among Moroccan lactating mothers in the...
Wed Aug 26, 2020 13:21
Related Articles Adult patient living 32 years with postduodenal remnant small bowel of only 35 cm in jejunocolic anastomosis type II weaned off parenteral nutrition. A case report. Int J Surg Case Rep. 2020 Aug 19;74:148-151 Authors: El-Helou E, Alimoradi M, Sabra H, Naccour J, Haddad MM, Chahine G Abstract INTRODUCTION: The small bowel is an essential organ for maintaining adequate nutrition. Decrease in length could be associated with malnutrition...
Wed Aug 26, 2020 17:10
Related Articles A patient with Camurati-Engelmann disease presenting bilateral TMJ ankylosis: A case report. Int J Surg Case Rep. 2020 Aug 19;74:144-147 Authors: Salman NJ, Pimenta E Souza D, Kuriki E, Sant'Ana E Abstract Camurati-Engelmann Disease (CED), also known as progressive diaphyseal dysplasia, is a rare congenital disorder inherited in an autosomal-dominant pattern, most commonly affecting the skull and diaphysis of long tubular bones....
Wed Aug 26, 2020 17:10
Related Articles Congenital Absence of Tracheal or Bronchial Rings. Otolaryngol Head Neck Surg. 2020 Aug 25;:194599820950725 Authors: Smith MM, Kou YF, Schweiger C, Lehenbauer DG, de Alarcon A, Rutter MJ Abstract OBJECTIVE: Congenital airway stenosis secondary to absent tracheal or bronchial rings is a rare congenital anomaly that is difficult to manage both clinically and surgically. This typically manifests as severe segmental tracheomalacia,...
Wed Aug 26, 2020 15:23
Related Articles Gaps in Training: Misunderstandings of Airway Management in Medical Students and Internal Medicine Residents. Otolaryngol Head Neck Surg. 2020 Aug 25;:194599820949528 Authors: Tokarz E, Szymanowski AR, Loree JT, Muscarella J Abstract OBJECTIVES: (1) Evaluate baseline airway knowledge of medical students (MSs) and internal medicine (IM) residents. (2) Improve MS and IM resident understanding of airway anatomy, general tracheostomy...
Wed Aug 26, 2020 15:23
Related Articles Evidence-Based Medicine in Otolaryngology, Part XI: Modeling and Analysis to Support Decisions. Otolaryngol Head Neck Surg. 2020 Aug 25;:194599820948827 Authors: Caulley L, Hunink MG, Randolph GW, Shin JJ Abstract OBJECTIVE: To provide a resource to educate clinical decision makers about the analyses and models that can be employed to support data-driven choices. DATA SOURCES: Published studies and literature...
Wed Aug 26, 2020 15:23
Related Articles The Long "Race" to Diversity in Otolaryngology. Otolaryngol Head Neck Surg. 2020 Aug 25;:194599820951132 Authors: Tusty M, Flores B, Victor R, Fassiotto M, Maldonado Y, Howard J, Valdez TA Abstract The number of health disparities disproportionately affecting minority communities continue to rise. Thus, it is imperative to assess whether equity within medical school enrollment and along the academic pipeline has mirrored...
Wed Aug 26, 2020 15:23
Related Articles The Unseen Global Burden of Disease. Otolaryngol Head Neck Surg. 2020 Aug 25;:194599820951464 Authors: Wiedermann J, Klug T, Abhra T, Alemayehu B, Sembergman J, Der C Abstract Due to geographic-specific patient and institutional-related barriers to care, data extrapolation and expert opinion on global burden of disease in otolaryngology-head and neck surgery may under- or overestimate the presence and effect of common head...
Wed Aug 26, 2020 15:23
Related Articles Prognostic Significance of Extranodal Extension in HPV-Mediated Oropharyngeal Carcinoma: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2020 Aug 25;:194599820951176 Authors: Benchetrit L, Torabi SJ, Givi B, Haughey B, Judson BL Abstract OBJECTIVE: To determine the prognostic role of extranodal extension (ENE) among patients with human papilloma virus-positive (HPV+) oropharyngeal squamous cell carcinoma...
Wed Aug 26, 2020 15:23
Related Articles Multispectral Imaging for Automated Tissue Identification of Normal Human Surgical Specimens. Otolaryngol Head Neck Surg. 2020 Aug 25;:194599820941013 Authors: Shenson JA, Liu GS, Farrell J, Blevins NH Abstract OBJECTIVE: Safe surgery requires the accurate discrimination of tissue intraoperatively. We assess the feasibility of using multispectral imaging and deep learning to enhance surgical vision by automated identification...
Wed Aug 26, 2020 15:23
Related Articles Pass/Fail Scoring of USMLE Step 1 and the Need for Residency Selection Reform. Otolaryngol Head Neck Surg. 2020 Aug 25;:194599820951166 Authors: Salehi PP, Azizzadeh B, Lee YH Abstract The Federation of State Medical Boards and the National Board of Medical Examiners recently announced a change in the United States Medical Licensing Examination Step 1 scoring convention to take effect, at the earliest, on January 1, 2022....
Wed Aug 26, 2020 15:23
A National Comparison of Postoperative Outcomes in Completion Thyroidectomy and Total Thyroidectomy.
Related Articles A National Comparison of Postoperative Outcomes in Completion Thyroidectomy and Total Thyroidectomy. Otolaryngol Head Neck Surg. 2020 Aug 25;:194599820951165 Authors: Brauer PR, Reddy CA, Burkey BB, Lamarre ED Abstract OBJECTIVE: To characterize and assess the non-thyroid-specific postoperative complications of completion thyroidectomy as compared with total thyroidectomy. STUDY DESIGN: Retrospective analysis:...
Wed Aug 26, 2020 15:23
Related Articles Efficacy of Adenoidectomy for the Treatment of Mild Sleep Apnea in Children. Otolaryngol Head Neck Surg. 2020 Aug 25;:194599820950719 Authors: Tipold A, Vazifedan T, Baldassari CM Abstract OBJECTIVES: (1) To assess outcomes in children undergoing adenoidectomy for the treatment of mild obstructive sleep apnea (OSA). (2) To identify clinical factors that predict which children will have persistent obstruction following adenoidectomy....
Wed Aug 26, 2020 15:23
Related Articles Complications After Soft Tissue With Plate vs Bony Mandibular Reconstruction: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2020 Aug 25;:194599820949223 Authors: Bauer E, Mazul A, Zenga J, Graboyes EM, Jackson R, Puram SV, Doering M, Pipkorn P Abstract OBJECTIVE: Mandibular reconstruction for segmental defects is a well-studied topic. However, there are conflicting data on the risks of delayed plate-related...
Wed Aug 26, 2020 15:23
Related Articles Surgical Technique and Accuracy of S2 Alar-Iliac Screw Insertion Using Intraoperative O-arm Navigation: An Analysis of 120 screws. World Neurosurg. 2020 Aug 22;: Authors: Tamaki R, Wada K, Okazaki K Abstract OBJECTIVE: To evaluate the surgical technique and accuracy of S2 alar-iliac (SAI) screw placement using intraoperative O-arm-based three-dimensional navigation (O-arm). METHODS: This study involved 60 patients who...
Wed Aug 26, 2020 17:00
Related Articles Unilateral Biportal Endoscopic-Guided Transcorporeal Vertebroplasty with Neural Decompression for Treating a Traumatic Lumbar Fracture of L5: Technical Note. World Neurosurg. 2020 Aug 22;: Authors: Quillo-Olvera J, Quillo-Olvera D, Quillo-Reséndiz J, Barrera-Arreola M Abstract BACKGROUND: Lumbar burst fractures (complete or incomplete) on L5 have a low incidence, counting for 1.2% of all spinal burst fractures. Treatment for...
Wed Aug 26, 2020 17:00
Related Articles Effect of cycling thalamo-subthalamic stimulation on tremor habituation and rebound in Parkinson's disease. World Neurosurg. 2020 Aug 22;: Authors: Enatsu R, Kitagawa M, Morishita T, Sasagawa A, Kuribara T, Hirano T, Arihara M, Mikami T, Mikuni N Abstract Deep brain stimulation (DBS) is an effective treatment for severe tremor in essential tremor and Parkinson's disease (PD). However, progressive loss of the beneficial effects...
Wed Aug 26, 2020 17:00
Related Articles A Comparison of the Elixhauser and Charlson Comorbidity Indices: Predicting In-Hospital Complications Following Anterior Lumbar Interbody Fusions. World Neurosurg. 2020 Aug 22;: Authors: Baron RB, Neifert SN, Ranson WA, Schupper AJ, Gal JS, Cho SK, Caridi JM Abstract OBJECTIVE: The Elixhauser Comorbidity Index (ECI) and Charlson Comorbidity Index (CCI) are commonly utilized measures that use administrative data to characterize...
Wed Aug 26, 2020 17:00
Related Articles Staged Cranial Surgery for Intracranial Lesions: A Historical Perspective. World Neurosurg. 2020 Aug 22;: Authors: Brown NJ, Shahrestani S, Tafreshi AR, Tran K, Lien BV, Ransom SC, Ransom RC, Diaz-Aguilar LD, Sahyouni R Abstract We follow the development of staged resection from its first description by Walter E. Dandy, one of the founding fathers of neurosurgery, in 1925 in which he removed a large vestibular schwannoma. This...
Wed Aug 26, 2020 17:00
Related Articles Complete Regression of a Solitary Cholangiocarcinoma Brain Metastasis following Laser Interstitial Thermal Therapy. World Neurosurg. 2020 Aug 22;: Authors: Tan SK, Luther E, Eichberg D, Shah A, Kahn K, Jamshidi A, Ivan M, Gultekin SH, Komotar R Abstract BACKGROUND: The authors report the first case of a cholangiocarcinoma brain metastasis successfully treated with MRI-guided laser interstitial thermal therapy (LITT). ...
Wed Aug 26, 2020 17:00
Related Articles Spontaneous occlusion of a complex brain arteriovenous malformation following partial embolization: a case report. World Neurosurg. 2020 Aug 22;: Authors: Altshuler M, Liu AH, Armonda R Abstract BACKGROUND: Curative embolization for cerebral arteriovenous malformation (AVM) cannot be achieved always. Rather, embolization plays a role in AVM treatment as an adjuvant therapy prior to radiosurgery and microsurgery. Curative embolization...
Wed Aug 26, 2020 17:00
Related Articles A novel quinolinylmethyl substituted ethylenediamine compound exerts anti-cancer effects via stimulating the accumulation of reactive oxygen species and NO in hepatocellular carcinoma cells. Eur J Pharmacol. 2020 Aug 22;:173497 Authors: Jin F, Wang R, Zhu Y, Chen J, Cao W, Wang Y, Wu Y, Song X, Huang Y, Dong J, Ren Z Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide....
Wed Aug 26, 2020 15:22
Related Articles Cytotoxic Screening and Transcriptomics Reveal Insights into the Molecular Mechanisms of Trihexyl Phosphate-triggered Hepatotoxicity. Environ Sci Technol. 2020 Aug 25;: Authors: Li Z, Tang X, Zhu L, Qi X, Cao G, Lu G Abstract Mounting evidence shows that organophosphate flame retardants (OPFRs), especially aryl- and halogenated-OPFRs, exert various adverse health effects on living organisms. This study evaluated the hepatotoxic...
Wed Aug 26, 2020 13:22
Related Articles The introduction of immunosuppressor (TDO inhibitor) significantly improved the efficacy of irinotecan in treating hepatocellular carcinoma. Cancer Immunol Immunother. 2020 Aug 25;: Authors: Liu Q, Hua S, Wang X, Chen F, Gou S Abstract As TDO inhibitors can improve the efficacy of tumor chemotherapeutics, two TDO-targeted conjugates consisting of irinotecan (Ir) and a TDO inhibitor unit were designed and prepared to reverse...
Wed Aug 26, 2020 13:22
Related Articles Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. Mol Psychiatry. 2020 Aug 24;: Authors: Figueiredo T, Mendes APD, Moreira DP, Goulart E, Oliveira D, Kobayashi GS, Stern S, Kok F, Marchetto MC, Santos R, Gage FH, Zatz M Abstract A homozygous mutation in the inositol monophosphatase 1 (IMPA1) gene was recently identified in nine individuals with severe...
Wed Aug 26, 2020 13:22
Related Articles The Dichloromethane Fraction of Vernonia cinerea Impart Pro-Apoptotic, Genotoxic, Cell Cycle Arrest, and Drug Efflux Inhibitory Effects in Human Adenocarcinoma Cells. Recent Pat Anticancer Drug Discov. 2020 Aug 24;: Authors: Beeran AA, Udupa N, Maliyakkal N Abstract <P>Background: Vernonia cinerea (VC) is an important medicinal plant used in the indigenous system of therapy. In ethnomedicine, VC has demonstrated anticancer...
Wed Aug 26, 2020 13:22
Related Articles DRUGPATH - a novel bioinformatic approach identifies DNA-damage pathway as a regulator of size maintenance in human ESCs and iPSCs. Sci Rep. 2019 02 13;9(1):1897 Authors: Kovacic B, Rosner M, Schlangen K, Kramer N, Hengstschläger M Abstract Genetic and biochemical screening approaches often fail to identify functionally relevant pathway networks because many signaling proteins contribute to multiple gene ontology pathways....
Wed Aug 26, 2020 13:22
Related Articles Inactive Tlk associating with Tak1 increases p38 MAPK activity to prolong the G2 phase. Sci Rep. 2019 02 13;9(1):1885 Authors: Liaw GJ, Chiang CS Abstract To guard genome integrity, response mechanisms coordinately execute the G2/M checkpoint in responding to stress. p38 MAPK is activated to prolong the G2 phase for completion of damage repair. Tlk activity is required for DNA repair, chromosome segregation and G2 recovery....
Wed Aug 26, 2020 13:22
Related Articles Hyperkinetic Seizures with Ictal Fear as Localizing Ictal Signs in MRI-Negative Medial Frontal Lobe Epilepsy. Neuropediatrics. 2020 Aug 25;: Authors: Cloppenborg T, Albers K, Kalbhenn T, Woermann FG, Bien CG, Polster T Abstract PURPOSE: Hyperkinetic seizures are described as seizure onset in the frontal or temporal lobe. Additional localizing information is important for diagnostic workup and surgical therapy. We describe diagnostic...
Wed Aug 26, 2020 16:30
Related Articles The roles of ER stress in epilepsy: Molecular mechanisms and therapeutic implications. Biomed Pharmacother. 2020 Aug 22;131:110658 Authors: Fu J, Tao T, Li Z, Chen Y, Li J, Peng L Abstract Epilepsies are a diverse group of neurological disorders, which are characterized by spontaneous recurrent seizures. Although a wide range of pathogenic mechanisms such as alterations in ion channels, inflammation and neuronal loss have been...
Wed Aug 26, 2020 16:30
Related Articles [Application of scalp electroencephalogram in treatment of refractory epilepsy with vagus nerve stimulation]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2020 Aug 25;37(4):699-707 Authors: Qin X, Yuan Y, Chen Y, Liao J, Lin S, Yang Z, Li L Abstract Electroencephalogram (EEG) has been an important tool for scientists to study epilepsy and evaluate the treatment of epilepsy for half a century, since epilepsy seizures are caused by...
Wed Aug 26, 2020 13:34
Related Articles Frequency of Automatic Stimulations in Responsive Vagal Nerve Stimulation in Patients With Refractory Epilepsy. Neuromodulation. 2020 Aug;23(6):852-858 Authors: Kulju T, Haapasalo J, Verner R, Dibué-Adjei M, Lehtimäki K, Rainesalo S, Peltola J Abstract BACKGROUND: In vagal nerve stimulation (VNS) therapy, the release of VNS model 106 (AspireSR) allowed for responsive VNS (rVNS). rVNS utilizes a cardiac-based seizure detection...
Wed Aug 26, 2020 13:34
Related Articles Emerging Use of Epidiolex (Cannabidiol) in Epilepsy. J Pediatr Pharmacol Ther. 2020;25(6):485-499 Authors: Abu-Sawwa R, Scutt B, Park Y Abstract The first plant-derived, purified pharmaceutical-grade cannabidiol (CBD) medication, Epidiolex, was approved in the United States by the FDA on June 25, 2018. Its approval for patients ≥ 2 years of age with Dravet syndrome (DS) or Lennox-Gastaut syndrome (LGS) markedly altered the treatment...
Wed Aug 26, 2020 13:34
Related Articles Why are epilepsy mortality rates rising in the United States? A population-based multiple cause-of-death study. BMJ Open. 2020 Aug 24;10(8):e035767 Authors: DeGiorgio CM, Curtis A, Carapetian A, Hovsepian D, Krishnadasan A, Markovic D Abstract INTRODUCTION: Epilepsy mortality rates are rising. It is unknown whether rates are rising due to an increase in epilepsy prevalence, changes in epilepsy causes of death, increase in the...
Wed Aug 26, 2020 13:34
Related Articles How do children with drug-resistant epilepsy sleep? A clinical and video-PSG study. Epilepsy Behav. 2020 Aug 22;:107320 Authors: Arhan E, Uçar HK, Aydın K, Hirfanoğlu T, Serdaroglu A Abstract AIM: The aim of this study was to assess sleep architecture and sleep problems among three homogenous groups of children including children with drug-resistant focal epilepsy, children with newly diagnosed, drug-naïve focal epilepsy, and...
Wed Aug 26, 2020 13:34
Related Articles Pluralistic and singular causal attributions for epilepsy in Uganda. Epilepsy Behav. 2020 Aug 22;:107334 Authors: Smith CE, Kajumba M, Bobholz S, Smith PJ, Kaddumukasa M, Kakooza-Mwesige A, Chakraborty P, Sinha DD, Kaddumukasa MN, Gualtieri A, Nakasujja N, Onuoha E, Nakku J, Muhumuza C, Sanchez N, Fuller AT, Haglund MM, Koltai DC Abstract OBJECTIVE: In Uganda, causal attributions for epilepsy reflect a variety of beliefs and...
Wed Aug 26, 2020 13:34
Related Articles Polygonogram and isobolographic analysis of interactions between various novel antiepileptic drugs in the 6-Hz corneal stimulation-induced seizure model in mice. PLoS One. 2020;15(6):e0234070 Authors: Luszczki JJ, Panasiuk A, Zagaja M, Karwan S, Bojar H, Plewa Z, Florek-Łuszczki M Abstract Pharmacotherapy with two antiepileptic drugs in combination is usually prescribed to epilepsy patients with refractory seizures. The choice...
Wed Aug 26, 2020 13:34
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