Dystonia secondary to cerebral infarcts presents months to years after the initial insult, is usually unilateral and causes significant morbidity. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is established as the most frequent target in the management of the dystonic symptoms. We report our experience with subthalamic nucleus (STN) DBS in 3 patients with post-infarct dystonia, in whom GPi DBS was not confidently possible due to the presence of striatal infarcts. Two patients...
Background: Drug addiction is one of the most prevalent and costly health problems worldwide. Over the past decade, deep brain stimulation (DBS) has increasingly been used for the treatment of drug addiction. Simultaneous DBS of nucleus accumbens (NAc) and the anterior limb of the internal capsule (ALIC) has successfully been used for preventing heroin relapse. However, the excessive energy consumption speeds up battery depletion, which puts a burden on patients. By comparison, anterior capsulotomy...
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A pair of reconstructions of serial blockface scanning electron microscopic images showing dendritic spines (blue) on dendrites (gray) of pyramidal cells in the prefrontal cortex, in a wildtype mouse (left) and in a mouse that is heterozygous for a null mutation in the Cyfip2 gene (right). Null mutations of this gene on one copy of chromosome 5 in humans are associated with intellectual disability and seizures. Mice with deletion of one copy of the gene have similar problems and their cortical neurons...
Long‐term exposure to lipid‐lowering drugs might affect Parkinson’s disease (PD) risk. We conducted Mendelian randomization analyses where genetic variants indexed expected effects of modulating lipid‐lowering drug targets on PD. Statin exposure was not predicted to increase PD risk, although results were not precise enough to support benefits for prevention clearly (odds ratio: 0.83; 95% confidence interval: 0.65, 1.07). Other target results were null, except for variants indicating Apolipoprotein‐A5...
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Publication date: Available online 26 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Li-Wei Hong, Ko-Ting Chen
Publication date: Available online 26 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Nathan A. Shlobin, Akash Mitra, Nikil Prasad, Hooman A. Azad, Michael B. Cloney, Benjamin S. Hopkins, Babak S. Jahromi, Matthew B. Potts, Nader S. Dahdaleh
Publication date: Available online 26 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Oluwaseun A. Omofoye, Robert A. Riestenberg, Ben Waldau
Publication date: Available online 25 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): William Andrés Florez-Perdomo, Sergio Andrés Serrato-Vargas, Pilar Bosque-Varela, Luis Rafael Moscote-Salazar, Andrei F. Joaquim, Amit Agrawal, Álvaro Ricardo Soto-Angel, Leidy Tatiana Tovar-Montenegro
Publication date: Available online 25 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Keith W. Lyons, Steven P. Baltic, Matthew A. Pappas, Janae A. Dunchack, Paul M. Werth, Kevin J. McGuire, Adam M. Pearson, William A. Abdu
Publication date: Available online 25 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Wei Xiong, Li-Feng Li, Ling Huang, Yan Liu, Zheng-Cai Xia, Xiao-Xia Zhou, Bei-Sha Tang, Ji-Feng Guo, Li-Fang Lei
Publication date: Available online 25 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): G La Rocca, T Ius, E Mazzucchi, GA Simboli, R Altieri, D Garbossa, A Acampora, AM Auricchio, F Vincitorio, F Cofano, G Vercelli, GM Della Pepa, F Pignotti, A Albanese, E Marchese, G Sabatino
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Abstract Literature investigating whether an individuals' sex affects their executive control abilities and performance on cognitive tasks in a normative population has been contradictory and inconclusive. By using meta‐analytic procedures (abiding by PRISMA guidelines), this study attempts to identify the magnitude of behavioural sex differences in three prominent executive control domains of cognitive set‐shifting, performance monitoring, and response inhibition. PubMed, Web of Science, and Scopus...
Abstract Visuomotor rotations are frequently used to study the different processes underlying motor adaptation. Explicit aiming strategies and implicit recalibration are two of these processes. Various methods, which differ in their underlying assumptions, have been used to dissociate the two processes. Direct methods, such as verbal reports, assume explicit knowledge to be verbalizable, where indirect methods, such as the exclusion, assume that explicit knowledge is controllable. The goal of this...
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Asymmetric gait post-stroke is associated with decreased mobility, yet individuals with chronic stroke often self-select an asymmetric gait despite being capable of walking more symmetrically. The purpose of t...
Functional magnetic resonance imaging (fMRI) provides critical information about the neurophysiology of the central nervous systems (CNS), posing clinical significance for the understanding of neuropathologies...
Stiff-Knee gait (SKG) after stroke is often accompanied by decreased knee flexion angle during the swing phase. The decreased knee flexion has been hypothesized to originate from excessive quadriceps activatio...
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Hilal A Ganaie, Vipul Gupta, Rajsrinivas Parthasarathy, Shrikant Londhe, Saurabh AnandNeurology India 2020 68(4):897-899 Cerebral hyperperfusion syndrome is a well-recognised phenomenon following carotid revascularisation. It is defined as cerebral blood flow increase of more than 100% of the baseline. A similar phenomenon can occur in the eye and maybe termed as ocular hyperperfusion syndrome. We present a 65-year-old male who developed an ipsilateral red eye with visual loss following carotid...
Randeep GuleriaNeurology India 2020 68(4):726-727
Boby Varkey MaramattomNeurology India 2020 68(4):945-946
Prakash N TandonNeurology India 2020 68(4):728-731
Bhaskara P Shelley, Shrijeet Chakraborti, Malla M ManjunathNeurology India 2020 68(4):922-926 Despite being common, polyneuropathy remains a diagnostic challenge for most clinicians. Mononeuritis multiplex (MM) refers to involvement of several or many peripheral nerves at the same or different points in time by a disease process. This report describes a case of an atypical presentation of Hansen's disease (HD) as mononeuritis multiplex in the left lower limb with corresponding radiographic, electrodiagnostic,...
Ramanan Rajakulasingam, Rajesh Botchu, Varaprasad N Vemuri, Steven L James, Kakarla Subbarao, A Mark DaviesNeurology India 2020 68(4):732-740 Although rare, skull vault lesions include a vast array of pathology encompassing infection, benign, and malignant bone tumors. Given the large range of potential diagnoses, it is crucial to identify imaging features to differentiate one from another, ensuring early diagnosis. Radiographs are still valuable in modern radiology but have largely been superseded...
Sanjay BehariNeurology India 2020 68(4):963-968
Muhammad B Tariq, Osmond C Wu, Marc A Agulnick, Manish K KasliwalNeurology India 2020 68(4):741-759 Background: Traumatic injury to the spine can be a complex diagnostic and therapeutic entity often with devastating consequences. Outside of the isolated vertebral column injury costs; annual costs associated with spinal cord injury (SCI) are estimated to exceed $9.7 billion. Objective: To identify the 100 most-cited articles on spine trauma. Methods: The Thomson Reuters Web of Science...
Parthasarathi Gayatri, Murali Mohan Selvam, SV SreeharshaNeurology India 2020 68(4):910-912 Although levetiracetam is the antiepileptic of choice in patients after hepatic transplantation and patients with hepatic dysfunction, we report a patient in whom levetiracetam was the most probable cause of hepatic dysfunction. Treatment of this hepatic dysfunction is to have a high degree of suspicion and withdraw the drug at the earliest to prevent morbidity and rarely mortality. Though rare, this is...
Mehdi Maghbooli, Majid Ghaffarpour, Taher Ghazizadeh, Nazanin Azizi Shalbaf, Ghazal MalekMahmoudiNeurology India 2020 68(4):760-768 Progressive external ophthalmoplegia (PEO) is a slowly progressive myopathy characterized by extraocular muscles involvement, leading to frozen eyes without diplopia. The pattern of inheritance may be mitochondrial, autosomal dominant or, rarely, autosomal recessive. Sporadic forms were also reported. Muscular involvement other than extraocular muscles may occur...
Harish Srinivasan, Haroon M Pillay, Dharav Kheradia, Kaushic A TheerthNeurology India 2020 68(4):937-938
Tejpal Gupta, Varindera P Singh, Anandh Balasubramian, Hari Menon, Purna A Kurkure, Shaleen Kumar, Rakesh JalaliNeurology India 2020 68(4):769-773 The entire world including India is currently fighting the coronavirus disease 19 (COVID-19) pandemic that threatens to disrupt healthcare systems globally in terms of capacity and resources. This outbreak necessitates an urgent review of existing management guidelines for commonly encountered tumors of the brain and central nervous system (CNS). Such...
Anna Teresa MazzeoNeurology India 2020 68(4):955-956
Harsh Deora, Nishanth Sadashiva, Manjul Tripathi, Nishant S Yagnick, Sandeep Mohindra, Aman Batish, Ninad R Patil, Ashish Aggarwal, Kiran Jangra, Hemant Bhagat, Nidhi Panda, Manas Panigrahi, Sanjay Behari, P Sarat Chandra, Dhaval P Shukla, Lokendra Singh, Suresh Bada Math, Sunil Kumar GuptaNeurology India 2020 68(4):774-791 Introduction: Severe acute respiratory syndrome, coronavirus 2 (SARS-COV 2) has inexplicably and irreversibly changed the way of neurosurgery practice. There has been a substantial...
Neetu Ramrakhiani, Paresh Kumar Sukhani, Ramfal DubeyNeurology India 2020 68(4):889-893 Neurosyphilis is a rare disease. We describe two patients of neurosyphilis with their clinical course and long-term follow-up. Our first patient was a 47-year-old male who presented with ataxia, headache, papilledema, sensorineural hearing loss, and myelopathy. Investigations revealed pachymeningitis and cervicodorsal myelitis. Cerebrospinal fluid (CSF) was reactive with positive CSF Venereal Disease Research...
Shweta Prasad, Vikram Venkappayya Holla, Koti Neeraja, Bharath Kumar Surisetti, Nitish Kamble, Ravi Yadav, Pramod Kumar PalNeurology India 2020 68(4):792-795 Background: The COVID-19 pandemic has compelled countries to impose lockdowns to curb the spread. As a result of the lockdown and need for health care services to cater to acute diseases on priority, patients with chronic illnesses such as Parkinson's disease (PD) may be facing several difficulties. Aims: This study aimed to explore...
Kadir OktayNeurology India 2020 68(4):903-905 Subdural hematoma is a rare complication after lumbar spine surgeries. Most of the time, the reason for this complication is intracranial hypotension related to an unintended durotomy, and the main symptom is persistent orthostatic headache. The authors present the case of a-38-year-old woman who underwent lumbar discectomy. Three weeks after the surgery, she developed subdural hematoma related to dural tear during the procedure. Emergent hematoma...
Satish Kumar Verma, Sundarakrishnan Dharanipathy, Ashish Suri, P Sarat Chandra, Shashank Sharad KaleNeurology India 2020 68(4):796-799 Background and Introduction: Donning and doffing of personal protective equipments (PPE) has become relevant especially during COVID-19 pandemic and neurosurgeons operating upon COVID-19 positive or suspect patients should be aware of proper technique of donning and doffing of PPE.[1] Surgeries involving direct exposure of anterior nasal spaces/paranasal sinuses...
Preema Sinha, Bhavni Oberoi, Yadvendra S Sirohi, Aradhana Sood, Saikat BhattacharjeeNeurology India 2020 68(4):916-918 Lyme disease is a multi-organ infectious disease caused by the spirochete “Borrelia burgdorferi,” and transmitted by the “Ixodes” tick. Early disseminated Lyme disease can have varied central nervous system manifestations ranging from meningitis to radiculopathy and cranial neuropathy. If not suspected, misdiagnosis or delayed diagnosis can prove to be fatal. Erythema migrans...
Sarat P Chandra, Jitin Bajaj, Raj Ghonia, Ramesh DoddamaniNeurology India 2020 68(4):800-802 Background and Introduction: Presence of multiple aneurysms, especially a combination of anterior and posterior circulation aneurysm in the same patient, is rare. Surgical clipping of both the aneurysms in the same sitting, although ideal, may be surgically challenging and requires a good preoperative planning. Objective: In this video abstract, we present a case of a ruptured middle cerebral artery...
Federico Martin Riolo, Derwin Plazas Alvarez, Miguel Osvaldo Villegas, José Antonio DíazNeurology India 2020 68(4):930-933 Congenital portosystemic shunt (CPSS) is a rare disorder characterized by a diversion of Porto-mesenteric blood into systemic veins. Type I is an end to side fistula between the portal vein and the inferior vena cava. Type II is a side to side fistula between the main portal vein or its branches and mesenteric, splenic, gastric, and systemic veins. Clinical presentation of...
Vikrant Keshri, Ravindra P Deshpande, Y B V K Chandrasekhar, Manas Panigrahi, I Satish Rao, Phanithi P BabuNeurology India 2020 68(4):803-812 Background: Low grade gliomas (LGG) are most often noted with the unpredictable overall survival and progression to higher grades. Objective: In the present study, we analyze the clinicopathological features influencing the prognostic outcomes and compared the features with criteria developed by EORTC. Materials and Methods: We observed the 130 LGG...
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