Molecules, Vol. 25, Pages 3891: An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia Molecules doi: 10.3390/molecules25173891 Authors: Diana S. Gesto Carlos M. S. Pereira Nuno M. F. S. Cerqueira Sérgio F. Sousa This review provides an updated atomic-level perspective regarding the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoAR), linking the more recent data on this enzyme with a structure/function interpretation....
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3893: Multi-Walled Carbon Nanotubes Solid-Phase Extraction and Capillary Electrophoresis Methods for the Analysis of 4-Cyanophenol and 3-Nitrophenol in Water Molecules doi: 10.3390/molecules25173893 Authors: Zeid A. ALOthman Ahmad Yacine Badjah Marcello Locatelli Imran Ali Analysis of 4-cyanophenol and 3-nitrophenol was carried out using multi-walled carbon nanotubes-based solid-phase extraction (SPE) and capillary electrophoresis (CE) methods. Capillary...
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3894: Optimization of the Freezing-Thawing Method for Extracting Phycobiliproteins from Arthrospira sp. Molecules doi: 10.3390/molecules25173894 Authors: Hui Teng Tan Nicholas M. H. Khong Yam Sim Khaw Siti Aqlima Ahmad Fatimah M. Yusoff The freezing–thawing method had been reported to be the best phycobiliprotein extraction technique. However, optimum parameters of this extraction method for Arthrospira sp. (one of the major phycobiliprotein...
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3887: Anti-Melanogenesis Activity of 6-O-Isobutyrylbritannilactone from Inula britannica on B16F10 Melanocytes and In Vivo Zebrafish Models Molecules doi: 10.3390/molecules25173887 Authors: Dae Kil Jang Chau Ha Pham Ik Soo Lee Seung-Hyun Jung Ji Hye Jeong Han-Seung Shin Hee Min Yoo A potential natural melanogenesis inhibitor was discovered in the form of a sesquiterpene isolated from the flowers of Inula britannica, specifically 6-O-isobutyrylbritannilactone...
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3890: Blood Clot Phenotyping by Rheometry: Platelets and Fibrinogen Chemistry Affect Stress-Softening and -Stiffening at Large Oscillation Amplitude Molecules doi: 10.3390/molecules25173890 Authors: Ursula Windberger Jörg Läuger (1) Background: Together with treatment protocols, viscoelastic tests are widely used for patient care. Measuring at broader ranges of deformation than currently done will add information on a clot’s mechanical phenotype because fibrin...
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3892: Lanthanide Luminescence in Visible-Light-Promoted Photochemical Reactions Molecules doi: 10.3390/molecules25173892 Authors: Ramiro Barraza Matthew Allen The excitation of lanthanides with visible light to promote photochemical reactions has garnered interest in recent years. Lanthanides serve as initiators for photochemical reactions because they exhibit visible-light-promoted 4f→5d transitions that lead to emissive states with electrochemical potentials...
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3889: Recent Advances in Asymmetric Iron Catalysis Molecules doi: 10.3390/molecules25173889 Authors: Alessandra Casnati Matteo Lanzi Gianpiero Cera Asymmetric transition-metal catalysis represents a fascinating challenge in the field of organic chemistry research. Since seminal advances in the late 60s, which were finally recognized by the Nobel Prize to Noyori, Sharpless and Knowles in 2001, the scientific community explored several approaches to emulate...
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3886: Prediction of Premature Termination Codon Suppressing Compounds for Treatment of Duchenne Muscular Dystrophy Using Machine Learning Molecules doi: 10.3390/molecules25173886 Authors: Kate Wang Eden L. Romm Valentina L. Kouznetsova Igor F. Tsigelny A significant percentage of Duchenne muscular dystrophy (DMD) cases are caused by premature termination codon (PTC) mutations in the dystrophin gene, leading to the production of a truncated, non-functional...
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3885: Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate Molecules doi: 10.3390/molecules25173885 Authors: Luís Borges-Araújo Fabio Fernandes Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a minor but ubiquitous component of the inner leaflet of the plasma membrane of eukaryotic cells. However, due to its particular complex biophysical properties, it stands out from its neighboring lipids as one of the most important regulators...
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3884: Electrochemical Properties of Screen-Printed Carbon Nano-Onion Electrodes Molecules doi: 10.3390/molecules25173884 Authors: Loanda R. Cumba Adalberto Camisasca Silvia Giordani Robert J. Forster The properties of carbon nano-onions (CNOs) make them attractive electrode materials/additives for the development of low-cost, simple to use and highly sensitive Screen Printed Electrodes (SPEs). Here, we report the development of the first CNO-based ink...
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3883: Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications Molecules doi: 10.3390/molecules25173883 Authors: Diana Lopes Tânia Melo Felisa Rey Joana Meneses Fátima Liliana Monteiro Luisa A. Helguero Maria Helena Abreu Ana Isabel Lillebø Ricardo Calado Maria Rosário Domingues Marine edible macroalgae have functional proprieties that might improve human...
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3882: Carbohydrates Profile, Polyphenols Content and Antioxidative Properties of Beer Worts Produced with Different Dark Malts Varieties or Roasted Barley Grains Molecules doi: 10.3390/molecules25173882 Authors: Justyna Gąsior Joanna Kawa-Rygielska Alicja Z. Kucharska The aim of this study was to assess the possibility of shaping properties of beers at the stage of brewing wort production with the use of various types of special malts (chocolate pale,...
Wed Aug 26, 2020 03:00
Molecules, Vol. 25, Pages 3881: Determination of Triacylglycerols by HTGC-FID as a Sensitive Tool for the Identification of Rapeseed and Olive Oil Adulteration Molecules doi: 10.3390/molecules25173881 Authors: Ying Qian Magdalena Rudzińska Anna Grygier Roman Przybylski Triacylglycerols (TGs) are the most common compounds in food lipids, accounting for 95% of the weight of edible oils. The aim of this study was to scrutinize a procedure for quantitatively assessing possible adulteration...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1975: SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway Cells doi: 10.3390/cells9091975 Authors: Bortolotti Gentili Rizzo Rotola Rizzo Natural killer cells are important in the control of viral infections. However, the role of NK cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has previously not been identified. Peripheral blood NK cells from SARS-CoV and SARS-CoV-2...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1965: It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology Cells doi: 10.3390/cells9091965 Authors: Christian Hiepen Paul-Lennard Mendez Petra Knaus Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGFβ) superfamily of cytokines. While some ligand members are potent inducers of angiogenesis, others promote vascular homeostasis. However, the precise understanding of the molecular mechanisms...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1973: Fine-Tuning of GLI Activity through Arginine Methylation: Its Mechanisms and Function Cells doi: 10.3390/cells9091973 Authors: Yoshinori Abe Nobuyuki Tanaka The glioma-associated oncogene (GLI) family consists of GLI1, GLI2, and GLI3 in mammals. This family has important roles in development and homeostasis. To achieve these roles, the GLI family has widespread outputs. GLI activity is therefore strictly regulated at multiple levels, including via post-translational...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1971: Podoplanin as an Attractive Target of CAR T Cell Therapy Cells doi: 10.3390/cells9091971 Authors: Masazumi Waseda Shin Kaneko To date, various kinds of cancer immunotherapy methods have been developed, but T cell immunotherapy is one of the most promising strategies. In general, T cell receptor (TCR) or chimeric antigen receptor (CAR) is used to modify the antigen specificity of T cells. CARs possess an underlying potential with treatment efficacy to treat...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1968: DJ-1 Proteoforms in Breast Cancer Cells: The Escape of Metabolic Epigenetic Misregulation Cells doi: 10.3390/cells9091968 Authors: Domenica Scumaci Erika Olivo Claudia Vincenza Fiumara Marina La Chimia Maria Teresa De Angelis Sabrina Mauro Giosuè Costa Francesca Alessandra Ambrosio Stefano Alcaro Valter Agosti Francesco Saverio Costanzo Giovanni Cuda Enhanced glycolysis is a hallmark of breast cancer. In cancer cells, the high...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1972: Rho GTPases in the Amygdala—A Switch for Fears? Cells doi: 10.3390/cells9091972 Authors: Tasnuva Sarowar Andreas M. Grabrucker Fear is a fundamental evolutionary process for survival. However, excess or irrational fear hampers normal activity and leads to phobia. The amygdala is the primary brain region associated with fear learning and conditioning. There, Rho GTPases are molecular switches that act as signaling molecules for further downstream processes...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1969: ATM Protein Kinase: Old and New Implications in Neuronal Pathways and Brain Circuitry Cells doi: 10.3390/cells9091969 Authors: Lara Pizzamiglio Elisa Focchi Flavia Antonucci Despite that the human autosomal recessive disease ataxia telangiectasia (A-T) is a rare pathology, interest in the function of ataxia-telangiectasia mutated protein (ATM) is extensive. From a clinical point of view, the role of ATM in the central nervous system (CNS) is the most...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1970: Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy Cells doi: 10.3390/cells9091970 Authors: Tadashi Yoshida Patrice Delafontaine Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via PI3K/Akt/mTOR and PI3K/Akt/GSK3β pathways. PI3K/Akt can also inhibit FoxOs and suppress transcription...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1974: Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies Cells doi: 10.3390/cells9091974 Authors: Sherin Saheera Ajay Godwin Potnuri Prasanna Krishnamurthy Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicular...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1966: Explorative Combined Lipid and Transcriptomic Profiling of Substantia Nigra and Putamen in Parkinson’s Disease Cells doi: 10.3390/cells9091966 Authors: Helena Xicoy Jos F. Brouwers Bé Wieringa Gerard J. M. Martens Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons from the substantia nigra (SN) that project to the dorsal striatum (caudate-putamen). To better understand the molecular mechanisms underlying PD, we...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1961: Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment Cells doi: 10.3390/cells9091961 Authors: Ana Rita Costa Monica M. Sousa By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that hold unique contractile properties. Their dynamic nature is essential for neuronal biology including the establishment of polarity, growth cone formation and motility, axon growth during development...
Wed Aug 26, 2020 03:00
Cells, Vol. 9, Pages 1967: New Insights into the Role of Sphingolipid Metabolism in Melanoma Cells doi: 10.3390/cells9091967 Authors: Lorry Carrié Mathieu Virazels Carine Dufau Anne Montfort Thierry Levade Bruno Ségui Nathalie Andrieu-Abadie Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its metastatic potency. Despite remarkable breakthroughs in term of treatments with the emergence of targeted therapy and immunotherapy, the prognosis...
Wed Aug 26, 2020 03:00
Diversity, Vol. 12, Pages 325: Facilitation or Competition? Effects of Lions on Brown Hyaenas and Leopards Diversity doi: 10.3390/d12090325 Authors: Bashant Somers Swanepoel Dalerum Intra-guild interactions related to facilitation and competition can be strong forces structuring ecological communities and have been suggested as particularly prominent for large carnivores. The African lion (Panthera leo) is generally thought to be a dominant predator where it occurs and can...
Wed Aug 26, 2020 03:00
Viruses, Vol. 12, Pages 945: Hepatitis B Virus Pre-S Mutants as Biomarkers and Targets for the Development and Recurrence of Hepatocellular Carcinoma Viruses doi: 10.3390/v12090945 Authors: Chiao-Fang Teng Han-Chieh Wu Ih-Jen Su Long-Bin Jeng Chronic hepatitis B virus (HBV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC), the leading cause of cancer-related death worldwide. Despite progress in the prevention and therapy of HCC, high incidence...
Wed Aug 26, 2020 03:00
Viruses, Vol. 12, Pages 942: Optimization Rules for SARS-CoV-2 Mpro Antivirals: Ensemble Docking and Exploration of the Coronavirus Protease Active Site Viruses doi: 10.3390/v12090942 Authors: Shana V. Stoddard Serena D. Stoddard Benjamin K. Oelkers Kennedi Fitts Kellen Whalum Kaylah Whalum Alexander D. Hemphill Jithin Manikonda Linda Michelle Martinez Elizabeth G. Riley Caroline M. Roof Nowreen Sarwar Doni M. Thomas Emily Ulmer Felissa E. Wallace...
Wed Aug 26, 2020 03:00
Viruses, Vol. 12, Pages 944: Reporter Phage-Based Detection of Bacterial Pathogens: Design Guidelines and Recent Developments Viruses doi: 10.3390/v12090944 Authors: Susanne Meile Samuel Kilcher Martin J. Loessner Matthew Dunne Fast and reliable detection of bacterial pathogens in clinical samples, contaminated food products, and water supplies can drastically improve clinical outcomes and reduce the socio-economic impact of disease. As natural predators of bacteria, bacteriophages...
Wed Aug 26, 2020 03:00
Viruses, Vol. 12, Pages 943: Effects of Manipulating Fibroblast Growth Factor Expression on Sindbis Virus Replication In Vitro and in Aedes aegypti Mosquitoes Viruses doi: 10.3390/v12090943 Authors: Wenbi Wu Cody A. Simmons Jessica Moffitt Rollie J. Clem A. Lorena Passarelli Fibroblast growth factors (FGFs) are conserved among vertebrate and invertebrate animals and function in cell proliferation, cell differentiation, tissue repair, and embryonic development. A viral fibroblast...
Wed Aug 26, 2020 03:00
Viruses, Vol. 12, Pages 940: HIV-1 Maturation: Lessons Learned from Inhibitors Viruses doi: 10.3390/v12090940 Authors: Alex B. Kleinpeter Eric O. Freed Since the emergence of HIV and AIDS in the early 1980s, the development of safe and effective therapies has accompanied a massive increase in our understanding of the fundamental processes that drive HIV biology. As basic HIV research has informed the development of novel therapies, HIV inhibitors have been used as probes for investigating...
Wed Aug 26, 2020 03:00
Viruses, Vol. 12, Pages 941: Molecular Characterization of Hemorrhagic Enteritis Virus (HEV) Obtained from Clinical Samples in Western Canada 2017–2018 Viruses doi: 10.3390/v12090941 Authors: Victor Palomino-Tapia Darko Mitevski Tom Inglis Frank van der Meer Mohamed Faizal Abdul-Careem Hemorrhagic enteritis virus (HEV) is an immunosuppressive adenovirus that causes an acute clinical disease characterized by hemorrhagic gastroenteritis in 4-week-old turkeys and older. Recurrent...
Wed Aug 26, 2020 03:00
Biomolecules, Vol. 10, Pages 1241: Chronic Cannabidiol Administration Attenuates Skeletal Muscle De Novo Ceramide Synthesis Pathway and Related Metabolic Effects in a Rat Model of High-Fat Diet-Induced Obesity Biomolecules doi: 10.3390/biom10091241 Authors: Bielawiec Harasim-Symbor Konstantynowicz-Nowicka Sztolsztener Chabowski Numerous studies showed that sustained obesity results in accumulation of bioactive lipid derivatives in several tissues, including skeletal...
Wed Aug 26, 2020 03:00
Biomolecules, Vol. 10, Pages 1239: N-Terminal Segment of TvCyP2 Cyclophilin from Trichomonas vaginalis Is Involved in Self-Association, Membrane Interaction, and Subcellular Localization Biomolecules doi: 10.3390/biom10091239 Authors: Sarita Aryal Hong-Ming Hsu Yuan-Chao Lou Chien-Hsin Chu Jung-Hsiang Tai Chun-Hua Hsu Chinpan Chen In Trichomonas vaginalis (T. vaginalis), cyclophilins play a vital role in dislodging Myb proteins from the membrane compartment and leading...
Wed Aug 26, 2020 03:00
Biomolecules, Vol. 10, Pages 1240: Antagonistic Functions of Connexin 43 during the Development of Primary or Secondary Bone Tumors Biomolecules doi: 10.3390/biom10091240 Authors: Talbot Dupuy Morice Rédini Verrecchia Despite research and clinical advances during recent decades, bone cancers remain a leading cause of death worldwide. There is a low survival rate for patients with primary bone tumors such as osteosarcoma and Ewing’s sarcoma or secondary bone...
Wed Aug 26, 2020 03:00
IJNS, Vol. 6, Pages 69: Evaluation of Multiple Methods for Quantification of Glycosaminoaminoglycan Biomarkers in Newborn Dried Blood Spots from Patients with Severe and Attenuated Mucopolysaccharidosis-I International Journal of Neonatal Screening doi: 10.3390/ijns6030069 Authors: Zackary M. Herbst Leslie Urdaneta Terri Klein Maria Fuller Michael H. Gelb All newborn screening (NBS) for mucopolysaccharidosis-I (MPS-I) is carried out by the measurement of α-iduronidase...
Wed Aug 26, 2020 03:00
IJNS, Vol. 6, Pages 68: The Success of a Screening Program Is Largely Dependent on Close Collaboration between the Laboratory and the Clinical Follow-Up of the Patients International Journal of Neonatal Screening doi: 10.3390/ijns6030068 Authors: Svetlana Lajic Leif Karlsson Rolf H. Zetterström Henrik Falhammar Anna Nordenström Neonatal screening for congenital adrenal hyperplasia due to 21-hydroxylase deficiency is now performed in an increasing number of countries all over...
Wed Aug 26, 2020 03:00
Metabolites, Vol. 10, Pages 346: β-Hydroxybutyrate Oxidation Promotes the Accumulation of Immunometabolites in Activated Microglia Cells Metabolites doi: 10.3390/metabo10090346 Authors: Adrian Benito Nabil Hajji Kevin O’Neill Hector C. Keun Nelofer Syed Metabolic regulation of immune cells has arisen as a critical set of processes required for appropriate response to immunological signals. While our knowledge in this area has rapidly expanded in leukocytes, much less is known...
Wed Aug 26, 2020 03:00
Nanomaterials, Vol. 10, Pages 1679: Nanostructure of Unconventional Liquid Crystals Investigated by Synchrotron Radiation Nanomaterials doi: 10.3390/nano10091679 Authors: Francesco Vita Fabrizio Corrado Adamo Michela Pisani Oriano Francescangeli The macroscopic properties of novel liquid crystal (LC) systems—LCs with unconventional molecular structure as well as conventional LCs in unconventional geometries—directly descend from their mesoscopic structural...
Wed Aug 26, 2020 03:00
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